Canesten Duo

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Canesten Duo is an oral tablet used to treat thrush. Canesten Duo is an antifungal medication, and works by killing the fungus causing the thrush and controlling the bacteria present within the vagina or penis.

What is Canesten Thrush Duo?

Canesten Thrush Duo is an oral capsule and external cream used to treat thrush. Thrush can cause a lot of discomfort with soreness, itching, and pain. Canesten Thrush Duo is a convenient and easy way to both calm external symptoms and clear the infection. This combination of an oral fluconazole capsule and clotrimazole cream works by killing the fungus that causes thrush, relieving symptoms that affect the genitals.

Canesten Thrush Duo is available over the counter without a prescription. You can also buy it from us at Instant eCare, following a brief online consultation.

For more information, consult the patient information leaflet.

How it works

Fluconazole works from within, to clear the thrush infection by killing the thrush fungus, while the double strength cream, containing clotrimazole, effectively treats external symptoms and calms the itch. Both antifungal substances belong to a group of medicines called azoles, that work to kill the Candida yeast that causes thrush infections.

Before you take it

Do not use Canesten Thrush Duo If you are allergic to fluconazole, clotrimazole or any of the other ingredients contained in this treatment. A full list is available in the patient information leaflet.

If you are unsure as to whether or not you have thrush, or if you have had more than two episodes of thrush in the last six months, you should speak to your doctor or pharmacist before using this treatment.

It is important for you and your partner to both check that you are free from sexually transmitted infections (STIs), as some STI symptoms can be mistaken for thrush. If you are unsure, speak to your doctor or pharmacist.

Speak to your doctor if you have symptoms of thrush and are under the age of 16, or over the age of 60. Please note, that we do not prescribe any medication to anyone under the age of 18.


You should see your doctor as soon as possible if you have any of the following symptoms before using this treatment, as it may not be suitable for you:

  • Irregular/abnormal vaginal bleeding
  • Lower abdominal pain
  • Difficulty in passing urine
  • Fever/chills

Do not use Canesten Thrush Duo if you are pregnant or breastfeeding, as it has been reported that this medication may affect your unborn baby, and it may enter your breast milk.


Do not use Canesten Thrush Duo without talking to your doctor first if you have blisters on your penis or if you have any abnormal discharge from your penis.

Before using Canesten Thrush Duo, you should see your doctor if you have ever suffered from a disease or illness affecting the liver, kidneys or heart. Your GP may prescribe alternative medication.

The external cream in this treatment may reduce the effectiveness of latex contraceptives, such as condoms. Therefore, alternative contraception should be considered while you are using it.

Using other medicines may interact with the effectiveness of this medication and Canesten Thrush Duo may alter the effectiveness of other medicines you are currently taking. Before taking, consult with your doctor if you are taking or have taken any of the following in recent weeks:

  • Antihistamine medicines for allergies, such as astemizole or terfenadine
  • Medicine for mental health disorders, such as pimozide
  • Medicine for treating heart arrhythmia, such as quinidine
  • Any antibiotics, like erythromycin
  • Medicine to prevent blood clots, also called anticoagulants
  • Medicine to control epilepsy, such as carbamazepine
  • Medicine to treat HIV infections, like zidovudine or saquinavir

This is not a complete list of warnings and interactions. For an exhaustive list, consult the patient information leaflet. or ask your doctor for advice.

Dosage instructions

Always take as directed by your doctor or pharmacist or as instructed on the packaging. Make sure never to exceed the stated dose.

Use in Women

The capsule is for oral use only and is used to treat thrush systemically. The capsule should be swallowed whole, with water, and should not be crushed or chewed. The cream is for external use and should be evenly applied to the entrance of the vagina, 2 to 3 times per day.

The symptoms of thrush should disappear within two days of treatment. If no improvement is seen after seven days, you must tell your doctor.

Use in Men

Thrush is a condition which can affect both men and women, although is much less common in men.

The penis can be treated with Canesten Thrush Duo cream. The cream should be applied to the end of the penis 2 or 3 times a day for up to two weeks. The cream is for external use only - do not put the cream in your mouth or swallow it.

Store in a cool, dry place, free from heat and moisture. Keep it out of the reach of children.

Common Side Effects of Canesten Duo

Like all medicines, Canesten Thrush Duo can cause side effects.


Common side effects occur more regularly, but if they persist or are a cause for concern, you should contact your doctor for advice. These side effects include:

  • Headaches
  • Stomach discomfort
  • Rashes
  • Weakness
  • Feeling drowsy
  • Dizziness

Canesten Thrush Duo may also cause more serious side effects. These side effects are less common, but you should contact a doctor as soon as possible if you experience them. These side effects include:

  • Recurrent infections like cold and flu
  • Red or purple discoloration of the skin
  • Hair loss
  • Severe blistering and peeling of the skin, mouth, eyes or genitals


After you apply the cream you might experience general, common side effects like itching and discomfort. This is normal, but if the symptoms persist, consult your doctor.

Some people may be allergic to the Canesten capsule or the cream, in extreme cases. If you experience an allergic reaction, or associated symptoms, this is serious and you should stop using the medication and tell your doctor or visit your nearest casualty department immediately.

This is not an exhaustive list and you should consult your doctor or pharmacist if you are concerned or want more information.

Frequently Asked Questions (FAQs)

Can I take the medicine while pregnant?

No. This product is not suitable for those who are pregnant or breastfeeding. You should contact your doctor for advice.

Is this medicine suitable for children?

This medicine is for use in patients with thrush. If you are under the age of 16 you should consult your doctor regarding this medication as it may not be suitable for you. We do not prescribe to anyone under the age of 18.

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